BIOFILLER VS PLATELET-RICH PLASMA MESOTHERAPY IN THE TREATMENT OF PERI-ORBITAL HYPERPIGMENTATION

Area of Science:

• Dermatology
• Aesthetic Medicine
• Regenerative Medicine

Background:

• Peri-orbital hyperpigmentation (POH) presents a common dermatological challenge with diverse etiologies.
• Effective treatment for POH often requires a personalized, case-by-case strategy.
• This study investigates novel therapeutic options for POH.

Purpose of the Study:

• To compare the efficacy of Biofillers versus platelet-rich plasma (PRP) meso-therapy for POH treatment.
• To evaluate patient satisfaction and complication rates associated with each treatment modality.
• To determine if Biofillers offer an advantage over PRP in POH management.

Main Methods:

• A double-blinded, randomized controlled trial was conducted with 42 patients.
• Participants were randomized into two groups: Biofillers (n=21) and PRP (n=21).
• Treatments were administered at 2-week intervals, with outcomes assessed using photometric scales, physician grading, and patient satisfaction surveys.

Main Results:

• Biofillers showed statistically significant improvements in the photo-numeric scale (p=0.001) and dermatologist evaluation (p=0.014) compared to PRP.
• Patient satisfaction was significantly higher in the Biofiller group (p=0.001).
• The Biofiller group experienced fewer adverse events, including pain, bruising, and lumps, compared to the PRP group (p=0.001).

Conclusions:

• Biofillers are more effective than PRP meso-therapy for treating peri-orbital hyperpigmentation.
• Biofillers offer a superior safety profile with a higher degree of patient satisfaction.
• The findings support Biofillers as a preferred treatment option for POH.