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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: May 21, 2025

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
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Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

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Basal Cell Carcinoma Excision Intraoperative Frozen Section For Tumour Clearance Rate And Reconstructive Surgery.

Moizza Tahir1, Uzma Bashir1, Aisha Akhtar1

  • 1Department of Dermatology, Pak Emirates Military Hospital Rawalpindi, Pakistan.

Journal of Ayub Medical College, Abbottabad : JAMC
|March 23, 2025
PubMed
Summary

Intraoperative frozen section for basal cell carcinoma (BCC) excision achieved tumor-free margins in 77.77% of cases. This reliable technique is best for high-risk BCCs, though resource-intensive.

Keywords:
BCC frozen section; BCC face reconstruction technique and tumour free margin; Tumour free margin, BCC excision

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Area of Science:

  • Dermatology
  • Surgical Oncology
  • Pathology

Background:

  • Basal cell carcinoma (BCC) is the most common skin cancer, with rising incidence.
  • Effective tumor margin assessment is crucial for complete BCC excision.
  • Tertiary care centers face challenges in managing BCC excision and reconstruction.

Purpose of the Study:

  • To evaluate the intraoperative frozen section clearance rate for BCC tumor margins and depth.
  • To determine the frequency of positive margins based on tumor location, size, and reconstruction technique.

Main Methods:

  • Prospective, open-label interventional study at a tertiary care hospital (Jan 2023 - Apr 2024).
  • Inclusion of BCC patients (10-35 mm, facial location) with intraoperative frozen section analysis by a histopathologist.
  • Statistical analysis of margin involvement, surgical technique, and location with p<0.05 significance.

Main Results:

  • 36 BCC patients were enrolled.
  • Tumor-free margins and depth were achieved in 77.77% of cases.
  • No significant association found between frozen section results and tumor location (p≤0.24), size (p≤0.84), or surgical technique (p≤0.51).

Conclusions:

  • Intraoperative frozen section is a reliable method for complete BCC excision.
  • The technique is resource-intensive and time-consuming, best reserved for high-risk tumors.
  • Patient education on follow-up for scar changes is recommended.