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Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
Published on: February 17, 2023
Sustained-release nanocapsule based on a 3D COF for long-term enzyme prodrug therapy of cancer
Xiuyan Wan1, Jiaqi Yin1, Qianqian Yan2
1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China. lina@sdnu.edu.cn.
Abstract:
A well-designed three-dimensional (3D) covalent organic framework (COF) was constructed as a nanocapsule for the encapsulation of horseradish peroxidase (HRP), which could realize sustained release of HRP to prolong the duration of the therapeutic agents and promote long-term enzyme prodrug therapy.
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