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Genetic encoding of a nonhydrolyzable phosphotyrosine analog in mammalian cells

Xinyuan He1, Bin Ma2, Yan Chen2

  • 1Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, 68588, USA. wniu2@unl.edu.

Chemical Communications (Cambridge, England)
|April 27, 2022
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The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
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