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Updated: Sep 25, 2025
Culture of myeloid dendritic cells from bone marrow precursors
Published on: July 25, 2008
Blastic Indeterminate Dendritic Cell Tumor Associated With Chronic Myelomonocytic Leukemia
Austin Ellis1, Ismail Elbaz Younes, Haipeng Shao
1Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Abstract:
Indeterminate dendritic cell tumor (IDCT) is an exceedingly rare neoplasm that can be associated with hematopoietic malignancies. We report a case of multifocal cutaneous blastic indeterminate dendritic cell tumor (BIDCT) in a 75-year-old man with chronic myelomonocytic leukemia showing blastic histiocytoid morphology, positivity for CD1a and S100, and no expression of langerin. We present a literature review on the 11 reported cases of IDCTs/BIDCTs associated with chronic myelomonocytic leukemia (CMML), including this case. The clinicopathological characteristics have been summarized. The IDCT and CMML cells are clonally related in 4 tested cases. Patients with IDCT/BIDCT associated with CMML seem to have worse clinical outcomes compared with patients with IDCT not associated with CMML.
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