Preparation of quinazolinones using biosynthesized silver nanoparticles

Area of Science:

• Green chemistry
• Nanocatalysis
• Organic synthesis

Background:

• Quinazolinones are important heterocyclic compounds with diverse biological activities.
• Efficient and environmentally friendly synthetic methods are crucial for their preparation.

Purpose of the Study:

• To develop a sustainable method for quinazolinone synthesis using silver nanoparticles.
• To investigate the catalytic activity and reusability of the synthesized silver nanocatalyst.

Main Methods:

• Silver nanoparticles (Ag NPs) were synthesized using Echium amoenum extract.
• The Ag NPs were characterized using UV-VIS, FT-IR, XRD, SEM, and EDS techniques.
• The catalytic activity of Ag NPs was evaluated for quinazolinone preparation under reflux conditions in ethanol.

Main Results:

• The synthesized silver nanocatalyst demonstrated high efficiency in quinazolinone synthesis.
• The method exhibited excellent atom economy, high product yields, and broad substrate scope.
• The catalyst was easily separable and reusable, highlighting its sustainability.
• Product structures were confirmed by 1H and 13C NMR, FT-IR, and elemental analysis.

Conclusions:

• Silver nanoparticles derived from Echium amoenum extract serve as an effective and reusable catalyst for quinazolinone synthesis.
• This green chemistry approach offers a sustainable alternative for producing valuable quinazolinone derivatives.