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Low-Cost Wearable Fluidic Sweat Collection Patch for Continuous Analyte Monitoring and Offline Analysis
Annemarijn S M Steijlen1, Kaspar M B Jansen2, Jeroen Bastemeijer1
1Faculty of Electrical Engineering, Mathematics & Computer Science, Delft University of Technology, Mekelweg 4, Delft 2628 CD, The Netherlands.
Analytical Chemistry
|April 29, 2022
Summary
A new sweat collection patch enables continuous monitoring and sampling for athletes. This validated system allows for accurate, real-time health and performance tracking, overcoming limitations of current methods.
Area of Science:
- Biomedical Engineering
- Wearable Technology
- Sports Science
Background:
- Electrochemical sweat sensors offer unobtrusive athlete monitoring, but lack standardized validation methods.
- Existing sweat collection techniques are labor-intensive and prone to contamination, limiting data acquisition.
- There is a need for reliable, easy-to-use systems for in situ validation of sweat sensors.
Purpose of the Study:
- To develop and validate an easy-to-fabricate sweat collection system.
- To enable continuous electrochemical monitoring and chronological sweat sampling.
- To provide a standardized method for validating novel sweat sensors in physiological settings.
Main Methods:
- Fabrication of a sweat collection patch with an analysis chamber, conductivity sensor, and sequential reservoirs with level indicators.
- Laboratory testing followed by physiological validation experiments with 6 participants across 3 patch locations.
- Comparison of continuous sweat conductivity with laboratory measurements of sodium ([Na+]) and chloride ([Cl-]) concentrations.
Main Results:
- A strong linear relationship (R² = 0.97) was observed between continuous sweat conductivity and laboratory ion concentration measurements.
- Sweat rate, derived from ventilated capsule measurements, showed a linear correlation with patch filling speed and continuous conductivity.
- The system successfully enabled systematic validation of sweat sensors in a physiological context.
Conclusions:
- The presented sweat collection patch is a validated tool for continuous monitoring and sampling.
- This system addresses the critical need for standardized methods in sweat sensor research.
- It facilitates accurate, real-time assessment of athlete performance and health status.

