[Chinese expert consensus on non-traditional blood lipid parameters to control the risks of arteriosclerotic...

Area of Science:

• Cardiology
• Clinical Chemistry

Background:

• Atherosclerotic cardiovascular disease (ASCVD) burden is rising globally, particularly in aging populations.
• Traditional blood lipid indicators, such as low-density lipoprotein cholesterol, show limitations in effectively controlling ASCVD risk.
• There is a need for improved and supplementary blood lipid assessment tools.

Purpose of the Study:

• To review and elucidate the role of non-traditional blood lipid indexes in managing ASCVD.
• To provide clinical expert recommendations for the application of these novel markers.

Main Methods:

• Systematic review of pathophysiological mechanisms, clinical associations, and detection methods for non-traditional blood lipid indexes.
• Analysis of intervention strategies and clinical application of these markers in ASCVD management.

Main Results:

• Non-traditional indexes include apolipoprotein B, lipoprotein a, non-high-density lipoprotein cholesterol, lipoprotein(a)remnant cholesterol, and non-fasting blood lipids.
• These markers offer enhanced insights into ASCVD risk beyond traditional metrics.
• Evidence supports their utility in risk stratification and guiding therapeutic decisions.

Conclusions:

• Non-traditional blood lipid indexes are crucial for comprehensive ASCVD risk assessment.
• Integrating these markers into clinical practice can optimize patient management and improve cardiovascular outcomes.
• Expert consensus provides guidance for their effective use in clinical settings.