Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

235
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
235
Bone Remodeling01:40

Bone Remodeling

38.6K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.6K
Understanding Sleep01:11

Understanding Sleep

693
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
693
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.2K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.2K
What is the Skeletal System?01:02

What is the Skeletal System?

53.9K
Overview
53.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone turnover marker rhythmicity: implications for osteoporosis treatment and fracture healing.

Endocrine connections·2026
Same authorSame journal

Stimulant Medications and Bone Health.

Current osteoporosis reports·2026
Same author

New Human Leukocyte Antigen (HLA) Antibody Formation and Creatinine Elevation With Abaloparatide in Kidney Transplant Recipient.

JBMR plus·2023
Same author

Bone Turnover Markers After Six Nights of Insufficient Sleep and Subsequent Recovery Sleep in Healthy Men.

Calcified tissue international·2022
Same author

Sleep duration and bone health measures in older men.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

Rapid suppression of bone formation marker in response to sleep restriction and circadian disruption in men.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same journal

Beyond Fracture Probability: Communicating the Full Consequences of Fracture and Contextualization.

Current osteoporosis reports·2026
Same journal

Time-Lapse HR-pQCT: an in Vivo Imaging-Based Assessment of Bone Remodeling Dynamics.

Current osteoporosis reports·2026
Same journal

Cone Beam Computed Tomography of Bonejaws in Patients With Primary Osteoporosis: A Systematic Review.

Current osteoporosis reports·2026
Same journal

Testosterone and Bone Health in Men.

Current osteoporosis reports·2026
Same journal

The Innate and Adaptive Immune Functions of Osteoblast-Lineage Cells.

Current osteoporosis reports·2026
See all related articles

Related Experiment Video

Updated: Sep 25, 2025

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

10.3K

Sleep Disruption and Bone Health.

Christine Swanson1

  • 1Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., Mail Stop 8106, Aurora, CO, 80045, USA. Christine.Swanson@CUAnschutz.edu.

Current Osteoporosis Reports
|April 30, 2022
PubMed
Summary
This summary is machine-generated.

Short sleep duration and night shift work are linked to lower bone mineral density (BMD) and increased fracture risk. These sleep disruptions may negatively impact bone metabolism and lifelong skeletal health.

Keywords:
AdolescentsBone mineral density (BMD)Bone turnoverDisrupted sleepFractureNight shift work

More Related Videos

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

1.8K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.5K

Related Experiment Videos

Last Updated: Sep 25, 2025

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

10.3K
Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

1.8K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.5K

Area of Science:

  • Integrative physiology
  • Bone metabolism
  • Sleep science

Background:

  • Growing evidence links sleep and circadian rhythm disruptions to adverse skeletal health outcomes.
  • Abnormal sleep duration and circadian misalignment are increasingly recognized as potential risk factors for bone disease.

Purpose of the Study:

  • To review recent literature on the relationship between bone health and sleep/circadian disruptions.
  • To synthesize current understanding of how factors like abnormal sleep duration and night shift work affect bone metabolism and skeletal integrity.

Main Methods:

  • Comprehensive literature review of recent studies.
  • Analysis of observational and interventional data investigating sleep, circadian rhythms, and bone health markers (e.g., bone mineral density, bone metabolism).

Main Results:

  • Short and long sleep durations are associated with lower bone mineral density (BMD).
  • Observational studies indicate an increased fracture risk in women with short sleep.
  • Circadian disruption, including night shift work, alters bone metabolism and structure, potentially increasing fracture risk.

Conclusions:

  • Sleep and circadian disruptions negatively impact bone metabolism and overall bone health.
  • Adolescent sleep disruptions may have long-term skeletal consequences.
  • Further research is needed to elucidate mechanisms and develop preventive strategies for optimizing skeletal health.