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Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

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Kristen D Kelley¹, Paul Aronowitz²

¹Division of General Internal Medicine, UC Davis Heath, 4150 V Street, Suite 2400, Sacramento, CA 95817, USA.

The Medical Clinics of North America

|May 1, 2022

Summary

This summary is machine-generated.

Early cancer detection improves prognosis. This article highlights key physical examination findings, including lymphadenopathy, skin changes, and thrombosis, that may indicate underlying malignancy in patients.

Keywords:

Cancer Cushing disease Deep vein thrombosis Lymphadenopathy Malignancy Physical examination Sign of Leser-Trélat Sweet syndrome

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Area of Science:

Oncology
Clinical Medicine
Diagnostic Physical Examination

Background:

Malignancy is a leading cause of death in the US.
Early cancer detection significantly impacts patient prognosis.
Recognizing physical signs of cancer is crucial for clinicians.

Purpose of the Study:

To review frequently encountered physical examination findings suggestive of malignancy.
To emphasize the importance of physical examination in early cancer detection.
To discuss specific findings such as lymphadenopathy, cutaneous manifestations, and thrombosis.

Main Methods:

Review of relevant medical literature on physical examination findings in oncology.
In-depth discussion of selected physical signs associated with various cancers.
Focus on practical, clinically relevant observations for healthcare providers.

Main Results:

Lymphadenopathy can indicate various hematologic and solid tumor malignancies.
Cutaneous findings, including specific lesions and changes, may be early signs of cancer.
Malignancy-associated thrombosis (e.g., Deep Vein Thrombosis) is a significant indicator.

Conclusions:

Physical examination remains a vital tool for identifying potential malignancy.
Awareness of specific findings like lymphadenopathy, skin changes, and thrombosis aids early diagnosis.
Prompt recognition of these signs can lead to earlier intervention and improved patient outcomes.