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Sebaceous breast carcinoma.

Natália Nobre de Alencar1, Diego Agra de Souza2, Alexandre Alves Lourenço1,2

  • 1Universidade Federal do Maranhão (UFMA), Hospital Universitário, São Luís, MA, Brasil.

Autopsy & Case Reports
|May 2, 2022
PubMed
Summary
This summary is machine-generated.

Sebaceous carcinoma of the breast is extremely rare. This case highlights its unique characteristics and triple-negative status, contributing to understanding this rare breast neoplasm.

Keywords:
AdenocarcinomaAdenocarcinoma SebaceousBreast NeoplasmsCarcinomaSebaceous Gland Neoplasms

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Breast sebaceous carcinoma is an exceptionally rare neoplasm, with fewer than 30 reported cases globally.
  • The latest World Health Organization classification categorizes these rare tumors under ductal carcinoma due to their infrequency.

Observation:

  • A case study of an 81-year-old woman with a right breast nodule presenting sebaceous carcinoma.
  • Histological examination revealed nests of sebaceous cells alongside smaller cells; no lymph node metastasis was detected.

Findings:

  • Immunohistochemical analysis showed positivity for GATA3, EMA, CD15, and focal GCDFP15, while negative for Estrogen Receptor (RE), Progesterone Receptor (RP), and HER-2, classifying it as triple-negative.
  • Differential diagnoses included skin sebaceous carcinoma, lipid-rich carcinoma, apocrine carcinoma, and glycogen-rich clear cell carcinoma.

Implications:

  • This detailed case description is crucial for improving the limited knowledge regarding the prognosis of breast sebaceous carcinoma.
  • Contrasting with previously reported cases often positive for RE and RP, this triple-negative finding may influence prognostic considerations and treatment strategies.