Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.7K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.7K
Pigmentation01:19

Pigmentation

2.9K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.9K
Papillary Dermis01:11

Papillary Dermis

3.8K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
3.8K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.3K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.3K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

2.4K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.4K
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

2.5K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metastatic Primary Extramammary Paget Disease: A Case Series.

Cutisยท2026
Same author

Rapid remission of Hailey-Hailey disease with tirzepatide therapy: A case report.

JAAD case reportsยท2026
Same author

Pigmentary Disorders in Skin of Color: Histopathologic Overview.

Dermatologic clinicsยท2026
Same author

Management of Multiple Miliary Osteoma Cutis Using CO<sub>2</sub> Laser: A Case-Based Exploration.

The Journal of clinical and aesthetic dermatologyยท2026
Same author

Diameter, height, and volume as macroscopic predictors of photocarcinogenesis in UV-induced SKH1 papules.

Journal of photochemistry and photobiology. B, Biologyยท2026
Same author

Letter to the editor - "Re: Tinea labialis in a patient with Schnitzler syndrome on interleukin-1 receptor antagonist".

JAAD case reportsยท2026
Same journal

Pellagra associated with iron deficiency.

Dermatology online journalยท2026
Same journal

Demodicosis: A frequently underrecognized cause of recalcitrant ear pruritus.

Dermatology online journalยท2026
Same journal

Association of alopecia areata with COVID-19 vaccination: A vaccine adverse events reporting system analysis.

Dermatology online journalยท2026
Same journal

Gender based price differences in 5% minoxidil foam: The impact of generic alternatives and bulk packaging.

Dermatology online journalยท2026
Same journal

Retrospective analysis of filler complications reported in the manufacturer and user facility device experience database from 2015 to 2025.

Dermatology online journalยท2026
Same journal

Characterizing barriers to care in patients with hidradenitis suppurativa.

Dermatology online journalยท2026
See all related articles

Related Experiment Video

Updated: Sep 24, 2025

Author Spotlight: Non-Surgical Treatment of Melasma&#8211; Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.1K

Unilateral swelling and hyperpigmented papules.

Ayodeji Ajayi, Olayemi Sokumbi1

  • 1Department of Dermatology, Mayo Clinic, Jacksonville, Florida, USA Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA.. sokumbi.olayemi@mayo.edu.

Dermatology Online Journal
|May 2, 2022
PubMed
Summary
This summary is machine-generated.

Lymphangioendothelioma, a rare vascular neoplasm, can appear as hyperpigmented lesions in dark-skinned individuals. Accurate histopathologic diagnosis is crucial to differentiate it from similar conditions, ensuring appropriate treatment.

More Related Videos

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.4K
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

236

Related Experiment Videos

Last Updated: Sep 24, 2025

Author Spotlight: Non-Surgical Treatment of Melasma&#8211; Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.1K
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.4K
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

236

Area of Science:

  • Dermatology
  • Pathology
  • Vascular Neoplasms

Background:

  • Lymphangioendothelioma, also known as acquired progressive lymphangioma, is a rare vascular neoplasm originating from lymphatic vessels.
  • Clinical presentation varies by skin tone; lesions are erythematous/violaceous in light-skinned individuals and often hyperpigmented in dark-skinned individuals.

Observation:

  • This report details a case of a 71-year-old woman presenting with slowly progressive hyperpigmented papules.
  • Histopathological examination revealed characteristic thin-walled vascular spaces within collagen bundles.

Findings:

  • The histopathology confirmed the diagnosis of lymphangioendothelioma.
  • The study emphasizes the importance of distinguishing this rare entity from other vascular tumors like Kaposi sarcoma and angiosarcoma.

Implications:

  • Accurate histopathologic distinction is critical for appropriate therapeutic management and prognostic assessment.
  • Recognizing potential diagnostic mimics can prevent delays in patient care for lymphangioendothelioma.