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Alteration in pattern reversal visual evoked potential in pediatric population with amblyopia and spherical
Ajai Agrawal1, Athul Suresh Puthalath1, Sanjeev K Mittal1
1Department of Ophthalmology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Indian Journal of Ophthalmology
|May 3, 2022
Summary
This study found that pattern visual evoked potential (VEP) P-100 amplitude is a significant predictor of refractive errors in children. P-100 latency correlated with myopia, while amplitude correlated with hypermetropia.
Area of Science:
- Ophthalmology
- Neuroscience
- Pediatric Medicine
Background:
- Refractive errors are common in children and can impact visual development.
- Pattern visual evoked potential (VEP) is a neurophysiological test used to assess the visual pathway.
- Understanding VEP parameters in pediatric refractive errors is crucial for early detection and management.
Purpose of the Study:
- To investigate the effect of refractive errors (myopia, hypermetropia, amblyopia) on pattern VEP recordings in a pediatric population.
- To establish normative P-100 VEP parameters for the pediatric Indian population.
- To determine the predictive value of P-100 amplitude and latency for refractive errors.
Main Methods:
- A cross-sectional observational study involving 120 children (8-18 years) divided into emmetropia, myopia, hypermetropia, and amblyopia groups.
- Pattern reversal VEP was performed on 240 eyes, recording P-100 amplitude and latency.
- Statistical analysis, including Receiver Operating Characteristics (ROC) analysis, was used to assess associations and predictive values.
Main Results:
- Normal P-100 parameters for the emmetropic group were established (Latency: 115.78 ± 10.19 ms, Amplitude: 11.11 ± 4.08 μV).
- P-100 latency significantly associated with myopia severity (P < 0.05).
- P-100 amplitude significantly associated with hypermetropia severity (P < 0.05) and identified as a good predictor of refractive error via ROC analysis.
Conclusions:
- Pediatric Indian VEP P-100 parameters may differ from conventional values.
- P-100 latency is a better correlate for myopia, while P-100 amplitude is a better correlate for hypermetropia.
- P-100 amplitude is the most significant predictor for the presence of refractive error in children.
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