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Monitoring Spatial Segregation in Surface Colonizing Microbial Populations
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Spatial confinement toward creating artificial living systems.

Luoran Shang1,2, Fangfu Ye3,4, Ming Li3

  • 1Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China. yjzhao@seu.edu.cn.

Chemical Society Reviews
|May 3, 2022
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Summary
This summary is machine-generated.

Spatial confinement is a key factor in building artificial living systems by influencing cell and tissue behavior. This review explores its role in biomanufacturing and biomedical applications.

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Area of Science:

  • Biotechnology
  • Systems Biology
  • Bioengineering

Background:

  • Physicochemical factors regulate lifeforms and can be harnessed for artificial living systems.
  • Spatial confinement is a critical factor influencing biological behaviors across multiple scales.

Purpose of the Study:

  • To review the role of spatial confinement in constructing artificial living systems.
  • To categorize knowledge on spatial confinement's effects on cellular and tissue-level behaviors.
  • To highlight advancements in synthesizing biomacromolecules, artificial cells, engineered tissues, and organoids within confined environments.

Main Methods:

  • Literature review and categorization of existing research.
  • Analysis of spatial confinement's impact on individual cell, collective cell, and tissue behaviors.
  • Emphasis on biomanufacturing processes within spatially confined bioreactors.

Main Results:

  • Spatial confinement provides essential cues for artificial living system construction.
  • Detailed categorization of spatial confinement's effects on biological organization from single cells to tissues.
  • Overview of current biomanufacturing endeavors utilizing confined systems.

Conclusions:

  • Spatial confinement is fundamental for creating artificial life.
  • Cutting-edge applications in biomedical fields are emerging from these systems.
  • Future directions involve addressing challenges in fundamental science, technology, and applications.