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Circadian molecular clock disruption in chronic pulmonary diseases
Allan Giri1, Qixin Wang2, Irfan Rahman2
1Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Trends in Molecular Medicine
|May 4, 2022
Summary
Circadian clock disruption worsens chronic lung diseases by increasing oxidative stress and inflammation. Understanding these changes could lead to new clock-based therapies.
Area of Science:
- Pulmonary Medicine
- Chronobiology
- Molecular Biology
Background:
- The circadian clock regulates physiological processes in the lung.
- Disruption of this clock is linked to chronic lung diseases.
- Clock disruption exacerbates disease pathology.
Purpose of the Study:
- To review the role of circadian clock disruption in chronic pulmonary diseases.
- To discuss altered clock genes in these conditions.
- To highlight potential for clock-based therapeutic strategies.
Main Methods:
- Literature review of circadian clock disruption in chronic lung diseases.
- Analysis of candidate clock genes affected at transcriptional/translational levels.
- Synthesis of current knowledge on molecular clock mechanisms.
Main Results:
- Circadian clock disruption contributes to oxidative stress, inflammation, metabolic issues, and altered lung function.
- Specific clock genes are altered in chronic pulmonary diseases.
- Evidence links clock dysfunction to disease progression.
Conclusions:
- Circadian clock disruption is a significant factor in chronic lung disease pathogenesis.
- Identifying altered clock genes provides therapeutic targets.
- Further research can advance novel clock-based treatments for lung diseases.
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