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Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Related Experiment Video

Updated: Sep 24, 2025

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

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Lung Allograft Rejection.

Deborah J Levine1, Ramsey R Hachem2

  • 1Division of Pulmonary and Critical Care Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

Thoracic Surgery Clinics
|May 5, 2022
PubMed
Summary
This summary is machine-generated.

Lung transplant rejection, including acute cellular rejection (ACR) and antibody-mediated rejection (AMR), impacts patient outcomes. This review covers ACR and AMR identification, features, and treatments.

Keywords:
Acute cellular rejectionAntibody-mediated rejectionDonor-specific antibodiesLung transplantation

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Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
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Area of Science:

  • Immunology
  • Transplantation Medicine
  • Pathology

Background:

  • Rejection is a significant complication after lung transplantation.
  • Acute cellular rejection (ACR) and antibody-mediated rejection (AMR) are key risk factors for chronic lung allograft dysfunction and poor transplant outcomes.
  • ACR diagnosis is histopathologically defined, while AMR diagnosis requires a multidisciplinary approach.

Purpose of the Study:

  • To review the identification, clinical and pathologic features, and therapeutic options for ACR and AMR in lung transplantation.

Main Methods:

  • Literature review of ACR and AMR in lung transplantation.
  • Analysis of diagnostic criteria for both rejection types.
  • Examination of current therapeutic strategies.

Main Results:

  • ACR has established histopathologic criteria.
  • AMR diagnosis is complex, necessitating a multidisciplinary approach.
  • Various therapeutic options exist for both ACR and AMR.

Conclusions:

  • Accurate identification and management of ACR and AMR are crucial for improving lung transplant outcomes.
  • Further research may refine diagnostic and therapeutic strategies for AMR.