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Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system
Javier Águila-Rosas1,2, Tomás Quirino-Barreda1, Gerardo Leyva-Gómez3
1Laboratorio de Farmacia Molecular y Liberación Controlada, UAM-Xochimilco Calzada del Hueso 1100, Col. Villa Quietud CP 04960 CDMX Mexico.
Abstract:
Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal-organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine. The presence of zinc plays a significant role to the modulation of sulfadiazine-MOF interactions. Release of sulfadiazine from sulfadiazine@MOFs was monitored in vitro and ex vivo conditions. A kinetic release model is proposed for in vitro sulfadiazine release. Remarkably, the materials did not show cytotoxicity against eukaryote cells.
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