Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Acting on Autonomic Ganglia: Blockers01:28

Drugs Acting on Autonomic Ganglia: Blockers

1.3K
Ganglionic blockers inhibit autonomic activity by blocking nicotinic receptors in the autonomic ganglia, suppressing impulse transmission. These blockers lack selectivity between sympathetic and parasympathetic ganglia and are ineffective as neuromuscular junction antagonists. They can be categorized into two groups:
1.3K
Sympathetic Pathways: Sympathetic Chain Ganglia01:20

Sympathetic Pathways: Sympathetic Chain Ganglia

3.6K
The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
3.6K
Sympathetic Signaling01:31

Sympathetic Signaling

1.3K
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
1.3K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

958
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
958
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:27

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla

1.6K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
1.6K
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions01:27

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions

570
Nondepolarizing neuromuscular blockers prevent the membrane depolarization of muscle cells and inhibit muscle contraction. These are usually administered with anesthetics to achieve complete muscle relaxation. Upon administration, these drugs first block the small, rapidly contracting muscles of the face and hands, followed by the larger muscles of the trunk and the intercostal muscles. The diaphragm is the last muscle to be affected.
Although all competitive neuromuscular blockers are designed...
570

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prescriptions with Precision: The World of Pharmacologic Therapies.

Physical medicine and rehabilitation clinics of North America·2026
Same author

Beyond Pills: Integrative Approaches to Pain Relief.

Physical medicine and rehabilitation clinics of North America·2026
Same author

Rewiring Pain: The Promise of Neuromodulation.

Physical medicine and rehabilitation clinics of North America·2026
Same author

Medication Overuse Headache.

Physical medicine and rehabilitation clinics of North America·2025
Same author

Headaches due to Low and High Intracranial Pressure.

Physical medicine and rehabilitation clinics of North America·2025
Same author

Interventional Treatment Strategies for Headache and Facial Pain.

Physical medicine and rehabilitation clinics of North America·2025

Related Experiment Video

Updated: Sep 24, 2025

Targeting Gray Rami Communicantes in Selective Chemical Lumbar Sympathectomy
03:59

Targeting Gray Rami Communicantes in Selective Chemical Lumbar Sympathectomy

Published on: January 10, 2019

7.3K

Sympathetic Blocks for Sympathetic Pain.

Melissa E Phuphanich1, Quinn Wonders Convery2, Udai Nanda3

  • 1Physical Medicine and Rehabilitation Department (117), Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA.

Physical Medicine and Rehabilitation Clinics of North America
|May 8, 2022
PubMed
Summary
This summary is machine-generated.

The sympathetic nervous system (SNS) impacts pain, mood, and behavior during stress. Blocking the SNS offers effective pain relief for various conditions, with customizable techniques available.

Keywords:
Neuropathic painSympathetic blocksSympathetic neurolysisSympathetic painSympathetically maintained painVascular pain

More Related Videos

Author Spotlight: Exploring Plasticity of Sympathetic Neurons
05:24

Author Spotlight: Exploring Plasticity of Sympathetic Neurons

Published on: July 5, 2024

2.7K
Ethanol-Induced Cervical Sympathetic Ganglion Block Applications for Promoting Canine Inferior Alveolar Nerve Regeneration Using an Artificial Nerve
06:48

Ethanol-Induced Cervical Sympathetic Ganglion Block Applications for Promoting Canine Inferior Alveolar Nerve Regeneration Using an Artificial Nerve

Published on: November 30, 2018

9.0K

Related Experiment Videos

Last Updated: Sep 24, 2025

Targeting Gray Rami Communicantes in Selective Chemical Lumbar Sympathectomy
03:59

Targeting Gray Rami Communicantes in Selective Chemical Lumbar Sympathectomy

Published on: January 10, 2019

7.3K
Author Spotlight: Exploring Plasticity of Sympathetic Neurons
05:24

Author Spotlight: Exploring Plasticity of Sympathetic Neurons

Published on: July 5, 2024

2.7K
Ethanol-Induced Cervical Sympathetic Ganglion Block Applications for Promoting Canine Inferior Alveolar Nerve Regeneration Using an Artificial Nerve
06:48

Ethanol-Induced Cervical Sympathetic Ganglion Block Applications for Promoting Canine Inferior Alveolar Nerve Regeneration Using an Artificial Nerve

Published on: November 30, 2018

9.0K

Area of Science:

  • Neuroscience
  • Pain Management
  • Autonomic Nervous System Research

Background:

  • The sympathetic nervous system (SNS) is a critical regulator of the body's stress response.
  • SNS activation influences multiple organ systems, affecting pain perception, behavior, and mood.
  • Dysregulation of the SNS is implicated in various pain states.

Purpose of the Study:

  • To explore the role of the sympathetic nervous system in pain modulation.
  • To review the efficacy of sympathetic blockade in managing diverse pain etiologies.
  • To highlight the availability of varied techniques for SNS blockade.

Main Methods:

  • Review of existing literature on sympathetic nervous system function and pain.
  • Analysis of studies investigating the effects of sympathetic blockade on pain relief.
  • Examination of different methods used for sympathetic blockade.

Main Results:

  • Sympathetic nervous system activation has significant effects on pain, behavior, and mood.
  • Blockade of the SNS demonstrates efficacy in alleviating pain from vascular, visceral, and neuropathic sources.
  • A range of techniques exist for SNS blockade, allowing for patient-specific treatment.

Conclusions:

  • The sympathetic nervous system plays a crucial role in pain processing and stress response.
  • Sympathetic blockade is a viable strategy for managing various types of chronic pain.
  • Individualized treatment approaches utilizing different SNS blockade techniques can optimize analgesia.