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Updated: Sep 24, 2025

Isolation and Selection of Entomopathogenic Fungi from Soil Samples and Evaluation of Fungal Virulence against Insect Pests
Published on: September 28, 2021
New α-pyrones from an endophytic fungus, Hypoxylon investiens J2
Chao Yuan1, Hong-Xia Yang2, Yu-Hua Guo3
1Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences CATAS Haikou 571101 People's Republic of China.
Abstract:
Four new α-pyrones, hypotiens A-D (1-4), were isolated from a fungal endophyte, Hypoxylon investiens J2, harbored in the medicinal plant Blumea balsamifera. Their structures were determined through detailed HRMS and NMR spectroscopic data. Compounds 1-4 are new α-pyrone derivatives containing an unusual dimethyl substitution in the highly unsaturated side chain. Their plausible biosynthetic pathway was discussed. Biological assay indicated that compounds 1-4 showed no antimicrobial, quorum sensing inhibitory, and cytotoxic activities. The specific side chain in α-pyrone derivatives 1-4 might be responsible for the weak pharmacological activities.
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