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Updated: Sep 24, 2025

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Impact of metallic trace elements on relaxivities of iron-oxide contrast agents
1Lab of Functional and Biomedical Nanomaterials, College of Materials Science and Engineering, Qingdao University of Science and Technology Qingdao 266042 China kchen@qust.edu.cn +86-532-84022509 +86-532-84022509.
Abstract:
In this work, well-defined 3 nm-sized Ca2+, Fe3+, Na+, Mg2+, Zn2+, Ni2+, Co2+, and Cd2+ cation-adsorbed Fe3O4/γ-Fe2O3 nanoparticles were used as prototype systems to investigate the influence of metallic trace elements in body fluids on the relaxivities of iron-oxide contrast agents. It was found that surface-adsorbed cations formed a deterioration layer to induce pronounced relaxivity loss. Theoretical study showed that such relaxivity loss can be well described by a modified GCAS function, taking into account the harmonic cation oscillations around Fe3O4/γ-Fe2O3 nanoparticles. Quantum mechanics analyses revealed that even-parity and odd-parity states of harmonic oscillations are dominant in r 1 and r 2 relaxivities, respectively. Moreover, the harmonic oscillations of Na+ and Mg2+ cations around Fe3O4/γ-Fe2O3 nanoparticles are found to be classical forbidden, which are quite different from their counterparts located in the classical permissive area.
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