Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

ASPECTS as a surrogate marker of core-perfusion mismatch in late-window large vessel occlusion stroke.

European stroke journal·2026

Same author

Mapping corpus callosum architecture: developmental, genetic, and cognitive correlates in youth.

bioRxiv : the preprint server for biology·2026

Same author

Maraviroc for Stroke Recovery (MASTER): protocol for a phase 2 double-blind placebo-controlled randomised clinical trial.

BMJ open·2026

Same author

[Stroke : epidemiological trends and challenges].

Revue medicale suisse·2026

Same author

[Artificial intelligence in the management of stroke].

Revue medicale suisse·2026

Same author

[Role of pharmacological treatment in post-stroke recovery].

Revue medicale suisse·2026

Same journal

Management of Patients at Risk of Ischemic Stroke With Left Ventricular Systolic Dysfunction in the Absence of Intracardiac Thrombus: A Scientific Statement From the American Heart Association.

Stroke·2026

Same journal

Update on Rehabilitation After Stroke: Global Changes and the Continued Importance of Therapy Intensity, Dose, and Timing.

Stroke·2026

Same journal

ENTF Neuromodulation Yields Reduced Disability After Stroke: An Individual Participant-Level Data Meta-Analysis.

Stroke·2026

Same journal

Menopause and Its Implications for Stroke in Women.

Stroke·2026

Same journal

Physician Approaches to Determining Goals of Stroke Care for Patients Living With Disability or Dementia: Results from the SEED Mixed-Methods Study.

Stroke·2026

Same journal

Aspirin for Stroke Primary Prevention: A Step Toward Genetic-Driven Personalized Medicine.

Stroke·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 24, 2025

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

Preparing for a Second Attack: A Lesion Simulation Study on Network Resilience After Stroke.

Mitsouko van Assche¹, Julian Klug¹, Elisabeth Dirren¹

¹Stroke Research Group, Department of Clinical Neurosciences, University Hospital and Faculty of Medicine, Geneva, Switzerland (M.v.A., J.K., E.D., E.C.).

|May 9, 2022

Summary

This summary is machine-generated.

The brain may become more resilient after a first stroke, enhancing network adaptability to future insults. This finding suggests potential for new stroke therapies focused on fostering brain resilience.

Keywords:

connectivity graph magnetic resonance imaging motor cortex recovery resilience stroke

More Related Videos

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

Related Experiment Videos

Last Updated: Sep 24, 2025

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

Area of Science:

Neuroscience
Systems Neuroscience
Clinical Neurology

Background:

Recurrent strokes pose significant clinical challenges, yet the brain's response to a potential second stroke remains poorly understood.
Acquiring suitable patient data for studying recurrent strokes is difficult due to lesion variability and unpredictable timing.
The brain's capacity to adapt and become more resilient after an initial stroke is an open question.

Purpose of the Study:

To investigate whether brain networks increase in resilience during stroke recovery.
To test the hypothesis that the brain prepares for future insults after a first stroke.
To explore the potential for enhancing brain resilience as a therapeutic strategy.

Main Methods:

Utilized a novel clinical lesion simulation approach on a cohort of 16 patients with primary motor cortex lesions.
Employed resting-state functional magnetic resonance imaging (rs-fMRI) to analyze brain networks at 10 days, 3 weeks, and 3 months post-stroke.
Simulated recurrent infarcts by node deletion in brain networks and applied graph measures to assess resilience and network cost.

Main Results:

Brain network resilience in patients was comparable to controls at 10 days and 3 weeks post-stroke.
At 3 months, patients demonstrated significantly higher resilience to simulated cortical, subcortical, and cortico-subcortical lesions compared to controls.
Increased resilience was observed irrespective of whether simulated attacks were random or targeted.

Conclusions:

Brain networks can reconfigure to enhance resilience against future insults following a stroke, particularly in cases with primary motor cortex lesions.
Lesion simulation presents an innovative method for studying stroke recovery and network adaptation.
Findings suggest potential for developing individualized neuromodulation therapies to promote brain resilience and mitigate consequences of subsequent strokes.