Related Experiment Video
Updated: Sep 24, 2025
05:13
Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
348
Acute pediatric cannabis intoxication: A scoping review
Lindsay A Gaudet1, Kaitlin Hogue2, Shannon D Scott3
1Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Summary
Cannabis liberalization is linked to more pediatric intoxication cases, but clinical management guidance is scarce. Further research is needed on healthcare providers
Area of Science:
- Pediatric Health
- Public Health
- Cannabis Research
Background:
- Cannabis liberalization presents potential risks to children.
- Understanding unintended consequences of cannabis policy on pediatric health is crucial.
Purpose of the Study:
- To map and identify evidence on acute cannabis intoxication in children.
- To assess the scope of research on public health, clinical management, and stakeholder experiences.
Main Methods:
- Scoping review of three medical literature databases.
- Inclusion of 158 sources from 4644 identified.
- Categorization of evidence into public health, clinical management, and stakeholder needs.
Main Results:
- Increased incidence of pediatric cannabis intoxications reported alongside cannabis liberalization.
- Evidence on signs, symptoms, and clinical management processes identified.
- Limited data exists on healthcare providers' and families' experiences and information needs.
Conclusions:
- A clear rise in pediatric cannabis intoxications correlates with cannabis legalization.
- Existing evidence on clinical management of pediatric cannabis intoxication is insufficient.
- Further research is warranted to address the experiences and information needs of healthcare providers and families.
Related Concept Videos
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
378
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
378
01:20Inhalational Anesthetics: Overview
547
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
547
01:24CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
352
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
352