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Updated: Sep 24, 2025

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Clinical practice guidelines for transsexual, transgender and gender diverse minors
Amadora Moral-Martos1, Julio Guerrero-Fernández2, Marcelino Gómez-Balaguer3
1Sección de Endocrinología Pediátrica, Hospital Universitari Vall d'Hebron, Barcelona; Grupo de Identidad y Diferenciación sexual de la Sociedad Española de Endocrinología y Nutrición (GIDSEEN); Equipo de Pediatría Territorial Garraf, Institut Català de la Salut (ICS), Barcelona, Spain.
Abstract:
Some people, including minors, have a gender identity that does not correspond to the sex assigned at birth. They are known as trans* people, which is an umbrella term that encompasses transgender, transsexual, and other identities not conforming to the assigned gender. Healthcare units for trans* minors require multidisciplinary working, undertaken by personnel expert in gender identity, enabling, when requested, interventions for the minor and their social-familial environment, in an individualized and flexible way during the gender affirmation path. This service model also includes hormonal treatments tailored as much as possible to the individual's needs, beyond the dichotomic goals of a traditional binary model. This guide addresses the general aspects of professional care of trans* minors and presents the current evidence-based protocol of hormonal treatments for trans* and non-binary adolescents. In addition, it details key aspects related to expected body changes and their possible side effects, as well as prior counselling about fertility preservation.
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