Xyloplains A-F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana
Yang-Guo Xie1, Weiyue Zhang1, Sheng-Lan Zhu1
1School of Pharmacy, Shanghai Jiao Tong University Shanghai 200240 P. R. China zhangyan_sjtu@sjtu.edu.cn wdzhangy@hotmail.com kimhz@sjtu.edu.cn +86-21-34205989 +86-21-34205989.
Abstract:
Six new guaiane dimers, xyloplains A-F (1-6), with connecting patterns through two direct C-C bonds (C-1 to C-3', C-2 to C-1'), were isolated from the roots of Xylopia vielana. Their structures were elucidated clearly using extensive analysis of 1D NMR and 2D NMR, combined with Cu-Kα X-ray diffraction and circular dichroism (CD) experiments. In additon, all of the isolates were tested for anti-inflammatory activity by measuring the amount of nitric oxide produced. To our delight, compounds 2 and 6 exhibited moderate inhibitory activity against the production of nitric oxide with IC50 value of 34.5 and 31.1 μM, respectively, in RAW264.7 cells stimulated by LPS.
Related Concept Videos
01:20Opioid Analgesics: Morphine and Other Natural Cogeners
01:15Opioid Analgesics: Synthetic and Semisynthetic Opioids
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...