Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conjugated Proteins02:50

Conjugated Proteins

18.6K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.6K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

16.1K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
16.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scarlet fever - A retrospective case series in the midst of recent upsurge of cases in India.

Indian journal of medical microbiology·2025
Same author

Exploring the Genetic Landscape of Histidine Phosphotransfer Proteins in the Oryza Genus.

Molecular biotechnology·2025
Same author

Comparison of clinical effectiveness between tissue adhesives and sutures for wound closure in periodontal flap surgery: a systematic review and meta-analysis.

Frontiers in oral health·2025
Same author

Strontium-Zinc conversion coating on magnesium plates for resorbable tack screws in guided bone regeneration: Characterization and biocompatibility evaluation.

Journal of clinical and experimental dentistry·2025
Same author

In-vitro evaluation of multicomponent scaffold with kappa carrageenan, tendon extracellular matrix and calcium-magnesium silicate for periodontal bone regeneration.

Journal of oral biology and craniofacial research·2025
Same author

Spatial profiling reveals unique immune microenvironment in premenopausal triple-negative breast cancer associated with therapy response.

Journal of translational medicine·2025
Same journal

Assessment of lower incisor position and symphysis dimensions among different skeletal patterns in the Chhattisgarh population.

Bioinformation·2026
Same journal

Low T3 syndrome and short-term outcomes in patients with acute decompensated heart failure: A retrospective observational study.

Bioinformation·2026
Same journal

Cardiovascular risk prevention awareness and practices in type 2 diabetes: Linking HbA1c and lipid levels.

Bioinformation·2026
Same journal

Assessment of periodontal condition using basic periodontal examination scores: A retrospective clinical study.

Bioinformation·2026
Same journal

Comparative evaluation of osseointegration among different surface modification techniques in dental implants.

Bioinformation·2026
Same journal

Micro-osteoperforations' impact on orthodontic tooth movement rate: Split mouth research.

Bioinformation·2026
See all related articles

Related Experiment Video

Updated: Sep 23, 2025

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
10:25

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

4.8K

Biochemical predictors for Sars-Cov-2 severity.

Ezhil Gurusamy1, S Mahalakshmi1, Gurumoorthy Kaarthikeyan2

  • 1Institute of Biochemistry, Madras Medical College, RGGGH, Chennai, India.

Bioinformation
|May 11, 2022
PubMed
Summary
This summary is machine-generated.

Inflammatory markers like C-Reactive Protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), along with liver function tests, are significantly elevated in severe COVID-19 cases. These biomarkers aid in assessing SARS-CoV-2 infection severity and patient prognosis.

Keywords:
BiochemicalSars-Cov-2predictorseverity

More Related Videos

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
08:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.0K
Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter
07:44

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter

Published on: August 12, 2021

3.2K

Related Experiment Videos

Last Updated: Sep 23, 2025

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
10:25

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

4.8K
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
08:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.0K
Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter
07:44

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter

Published on: August 12, 2021

3.2K

Area of Science:

  • Clinical Medicine
  • Biochemistry
  • Infectious Diseases

Background:

  • SARS-CoV-2 infection presents a wide spectrum of clinical severity.
  • Identifying reliable prognostic markers is crucial for managing COVID-19 patients.
  • Systemic inflammation and liver function alterations are observed in severe infections.

Purpose of the Study:

  • To evaluate inflammatory markers and liver function analytes in SARS-CoV-2 patients.
  • To correlate biomarker levels with COVID-19 severity.
  • To assess the prognostic value of these markers for patient outcomes.

Main Methods:

  • Retrospective analysis of 1000 COVID-19 positive patients.
  • Measurement of neutrophil-to-lymphocyte ratio (NLR), C-Reactive Protein (CRP), Ferritin, Creatine Kinase (CK), and Lactate Dehydrogenase (LDH).
  • Assessment of liver function tests including bilirubin, albumin, and aminotransferases (AST, ALT).

Main Results:

  • Significantly higher levels of CRP, NLR, Ferritin, CK, and LDH in severe COVID-19 cases compared to non-severe cases (p<0.05).
  • Elevated liver function test results (bilirubin, AST, ALT, ALP, total protein, albumin) were observed in severe cases (p<0.05).
  • These biomarkers demonstrated a statistically significant correlation with disease severity.

Conclusions:

  • NLR, CRP, Ferritin, CK, LDH, and liver function analytes are critical prognostic markers for SARS-CoV-2 infections.
  • Routine monitoring of these markers can aid in risk stratification.
  • Utilizing these markers may help reduce morbidity and mortality associated with COVID-19.