Driving mesenchymal stem cell differentiation from self-assembled monolayers

The utilization of self-assembled monolayer (SAM) systems to direct Mesenchymal Stem Cell (MSC) differentiation has been covered in the literature for years, but finding a general consensus pertaining to its exact role over the differentiation of stem cells had been rather challenging. Although there are numerous reports on surface functional moieties activating and inducing differentiation, the results are often different between reports due to the varying surface conditions, such as topography or surface tension. Herein, in view of the complexity of the subject matter, we have sought to catalogue the recent developments around some of the more common functional groups on predominantly hard surfaces and how these chemical groups may influence the overall outcome of the mesenchymal stem cells (MSC) differentiation so as to better establish a clearer underlying relationship between stem cells and their base substratum interactions.