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Rapid Collection of Floral Fragrance Volatiles using a Headspace Volatile Collection Technique for GC-MS Thermal Desorption Sampling
Published on: December 10, 2019
Development and validation of a dispersive liquid-liquid microextraction method for the determination of phthalate
1Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University King Faisal Road, P.O. Box 1982 Eastern Province Dammam 31441 Kingdom of Saudi Arabia ammostafa@iau.edu.sa ammostaf@uwaterloo.ca +966 562623776.
Abstract:
A simple, rapid, sensitive and eco-friendly method has been developed for the simultaneous determination, preconcentration and extraction of phthalate esters (dimethyl phthalate, diethyl phthalate, dibutyl phthalate, benzyl butyl phthalate and bis(2-ethylhexyl) phthalate) in perfumes using dispersive liquid-liquid microextraction (DLLME) coupled to gas chromatography-mass spectrometry (GC-MS). Various factors affecting the DLLME efficiency, including the type and volume of the extracting and dispersing solvents, salt addition and vortex extraction time were optimized. Under optimum conditions, the proposed method provided low detection limits (0.003-0.070 ng mL-1), high extraction recovery (85.6-95.8%), wide linearity range (1.0-1000 ng mL-1) with good regression coefficients (>0.9984) and good precision (RSD% < 4.2%). The optimized method was successfully utilized for the analysis of different branded perfume samples and satisfactory results were obtained.
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