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Principles of Disease Surveillance

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Updated: Sep 23, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Dengue: A Growing Problem With New Interventions.

Joshua M Wong^1,2, Laura E Adams², Anna P Durbin³

¹Epidemic Intelligence Service, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia.

|May 11, 2022

Summary

This summary is machine-generated.

Dengue fever, a mosquito-borne illness, is a growing global health concern. A new vaccine, Dengvaxia, is now recommended in the US for children with prior dengue infection, offering a new prevention tool.

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Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

Area of Science:

Medical Entomology
Tropical Medicine
Vaccinology

Background:

Dengue fever, caused by dengue viruses (DENV-1-4) transmitted by Aedes mosquitoes, is the most prevalent arboviral disease globally.
Increasing disease burden and geographic range necessitate improved clinical understanding and management strategies.
Clinicians must be aware of dengue's presentation, testing, and management, especially with returning travelers and potential local transmission in the US.

Purpose of the Study:

To review dengue pathogenesis, epidemiology, and clinical features for healthcare providers.
To summarize the efficacy, safety, and usage considerations for Dengvaxia, the first dengue vaccine recommended in the US.
To provide an overview of emerging tools for dengue control and prevention.

Main Methods:

Literature review of dengue pathogenesis, epidemiology, and clinical manifestations.
Analysis of clinical trial data and recommendations regarding Dengvaxia.
Synthesis of information on current and future dengue control strategies.

Main Results:

Dengue is a significant arboviral disease with increasing global impact.
Dengvaxia, a dengue vaccine, received a recommendation for specific age groups in the US.
Vaccination with Dengvaxia requires prior laboratory confirmation of dengue virus infection.

Conclusions:

Effective clinical management and prevention of dengue are crucial due to its increasing prevalence.
Dengvaxia represents a significant advancement in dengue prevention, particularly for endemic populations.
Ongoing research into novel control measures is essential to combat the growing threat of dengue.