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Non-infectious granulomatous disorders of the upper lip: clinicopathological analysis of 11 patients
Irene Lafuente-Ibáñez de Mendoza1, Emmanuelle Vigarios2, Béatrice Herbault-Barres3
1Oral Medicine and Pathology Unit, Department of Stomatology II, University of the Basque Country UPV/EHU, Barrio Sarriena s/n, 48940, Leioa, Spain. irene.lafuente@ehu.eus.
Background:
Non-infectious granulomatous disorders of the upper lip represent a special chapter of oral and maxillofacial pathology. In this work we report a case-series of this process, to analyse its main clinicopathological features and find differential data that allow us improve its diagnosis and understand its pathogenesis.
Methods:
We present 11 cases of non-infectious granulomatous disorders of the upper lip, 8 women and 3 men with an age range of 29-84 years, who have been attended at the Oral Medicine Department of the IUCT (France) and the Oral Medicine Unit of the UPV/EHU (Spain). All clinicopathological data were collected in a specific protocol.
Results:
We recognized 4 different subtypes of non-infectious granulomatous disorders of the upper lip: (1) associated with Crohn's disease (1 case), (2) associated with foreign body (2 cases), (3) associated with gingivitis lichenoid-like (4 cases), (4) idiopathic (4 cases).
Conclusions:
Clinicopathological differences were identified between these subtypes. A good differential diagnosis is necessary in all cases to rule out the presence of local or systemic etiopathogenic factors.
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