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A Rapid, Multiplex Dual Reporter IgG and IgM SARS-CoV-2 Neutralization Assay for a Multiplexed Bead-Based Flow Analysis System
Published on: April 6, 2021
Molecular and Serologic Diagnostic Technologies for SARS-CoV-2
Halie M Rando1, Christian Brueffer2, Ronan Lordan3
1Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America; Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, United States of America; Center for Health AI, University of Colorado School of Medicine, Aurora, Colorado, United States of America · Funded by the Gordon and Betty Moore Foundation (GBMF 4552); the National Human Genome Research Institute (R01 HG010067).
Biotechnology advanced COVID-19 diagnostics, with molecular tests detecting active infections and serological tests identifying past exposure to SARS-CoV-2. These crucial tools aid in managing the pandemic by understanding viral spread.
Area of Science:
- Biotechnology and Biomedical Science
- Infectious Disease Research
- Public Health
Background:
- The COVID-19 pandemic necessitated rapid advancements in diagnostic technologies.
- Effective management of viral threats relies on accurate detection of infected and recovered individuals.
Approach:
- This review categorizes diagnostic tests for SARS-CoV-2 into molecular and serological methods.
- It examines the biotechnological approaches within each category, highlighting their respective advantages and disadvantages.
- The role of these diagnostics in understanding and controlling the COVID-19 pandemic is discussed.
Key Points:
- Molecular diagnostics identify current infections by detecting the presence of the SARS-CoV-2 virus.
- Serological tests detect antibodies, indicating a past immune response and previous exposure to SARS-CoV-2.
- Both test types offer distinct, valuable information for epidemiological surveillance.
Conclusions:
- Biotechnological innovations in diagnostics are critical for pandemic response.
- Understanding the capabilities of molecular and serological tests is essential for effective COVID-19 management.
- Continued development of sensitive and specific diagnostic tools remains a priority.
