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[The adhesive capacity of representative intestinal microflora in the continuous and split oral administration of
Antibiotiki I Meditsinskaia Biotekhnologiia = Antibiotics and Medical Biotechnology
|March 1, 1987
Abstract:
When cephalexin and erythromycin were administered intragastrically with intervals, adhesion of facultative pathogenic bacteria such as Klebsiella, Staphylococcus and E. coli to enterocytes of the small intestine in vitro was more pronounced than with their continuous administration with drinking water. The adhesive capacity of the staphylococcal strains resistant to the antibiotics was higher than that of the sensitive ones.
Insights
Intragastric administration of cephalexin and erythromycin at intervals increased bacterial adhesion to intestinal cells compared to continuous administration. Antibiotic-resistant bacteria showed greater adhesion potential.
Area of Science:
- Microbiology
- Pharmacology
- Gastroenterology
Background:
- Antibiotic administration can alter the gut microbiome.
- Bacterial adhesion to enterocytes is a key factor in colonization and infection.
- Understanding the impact of antibiotic administration methods on bacterial adhesion is crucial for infection control.
Purpose of the Study:
- To investigate the effect of intermittent versus continuous administration of cephalexin and erythromycin on the in vitro adhesion of specific bacteria to small intestinal enterocytes.
- To compare the adhesive capacity of antibiotic-resistant versus antibiotic-sensitive bacterial strains.
Main Methods:
- In vitro study using small intestinal enterocytes.
- Administration of cephalexin and erythromycin via intragastric (intermittent) and drinking water (continuous) methods.
- Assessment of bacterial adhesion of Klebsiella, Staphylococcus, and E. coli.
Main Results:
- Intermittent intragastric administration of cephalexin and erythromycin resulted in more pronounced adhesion of Klebsiella, Staphylococcus, and E. coli to enterocytes compared to continuous administration.
- Staphylococcal strains exhibiting resistance to these antibiotics demonstrated a higher adhesive capacity than sensitive strains.
Conclusions:
- The method of antibiotic administration (intermittent vs. continuous) significantly influences the adhesion of facultative pathogenic bacteria to intestinal enterocytes.
- Antibiotic resistance in bacteria may correlate with increased adhesive potential, potentially impacting colonization and infection dynamics.