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Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

Published on: December 16, 2017

Nanotechnology-Assisted Cell Tracking.

Alessia Peserico¹, Chiara Di Berardino¹, Valentina Russo¹

¹Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.

Nanomaterials (Basel, Switzerland)

|May 14, 2022

Summary

Nanoparticles (NPs) offer advanced diagnostic and therapeutic potential by targeting cells effectively. Optimizing NP-cell interactions is key for developing new nanomedicine applications in cancer and regenerative medicine.

Keywords:

cell labelling cell tracking cell uptake nanoparticles stem cell homing

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Published on: September 19, 2019

Area of Science:

Biomedical Engineering
Nanotechnology
Cell Biology

Background:

Nanoparticles (NPs) are crucial for diagnostics and therapeutics due to their ability to cross biological barriers and enable targeted delivery.
Understanding NP-cell interactions is vital for optimizing NP delivery systems.
Cell membrane-coated NPs represent a mature nanomedicine field.

Purpose of the Study:

To review technologies for cell-NP interaction and detection.
To analyze NP design elements impacting cell interaction and delivery assessment.
To highlight applications in cancer and regenerative medicine.

Main Methods:

Literature survey on NP typology, functionalization, and cell interaction mechanisms.
Analysis of in vitro and in vivo cell interaction tuning.
Evaluation of imaging devices for NP delivery assessment, focusing on specificity and sensitivity.

Main Results:

Cell membrane-coated NPs are well-developed for clinical translation.
Biomimetic functionalization for NP cell labelling and retention is less advanced.
NP design significantly influences cell interaction and delivery efficacy.

Conclusions:

Optimized NP-cell interactions enhance diagnostic and therapeutic capabilities.
Further development in biomimetic NP functionalization is needed for advanced applications.
Scalable NP technologies promise significant biomedical advancements and improved human health.