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Updated: Sep 23, 2025

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test

Published on: April 30, 2019

Rasmussen's encephalitis: Early diagnostic criteria in children.

N Villeneuve¹, A Lépine¹, N Girard²

¹Service de neuropédiatrie, centre hospitalo universitaire de la Timone, 264, rue Saint-Pierre, 13005 Marseille, France.

Revue Neurologique

|May 14, 2022

Summary

This summary is machine-generated.

Rasmussen's encephalitis (RE) is a rare brain disorder causing progressive neurodegeneration and drug-resistant epilepsy. Early diagnosis and targeted immunotherapies are crucial for managing this complex inflammatory condition.

Keywords:

Child Diagnostic History Rasmussen's encephalitis

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Last Updated: Sep 23, 2025

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test

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Published on: April 30, 2019

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

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Published on: July 4, 2007

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Area of Science:

Neurology
Neuroimmunology
Pediatric Neurology

Background:

Rasmussen's encephalitis (RE) is a rare, chronic inflammatory brain disorder.
It leads to progressive neurodegeneration in one cerebral hemisphere, causing functional loss and drug-resistant epilepsy.
Diagnosis is challenging due to the lack of specific markers, particularly in early stages.

Purpose of the Study:

To review the diagnostic complexities of Rasmussen's encephalitis.
To discuss current and emerging therapeutic strategies for RE.
To highlight challenges in early detection and management.

Main Methods:

Review of clinical, electroencephalographic, radiological, and biochemical diagnostic criteria for RE.
Analysis of treatment outcomes for anti-seizure medications, immunomodulatory therapies, and hemispherotomy.
Exploration of the immunopathogenesis and potential of biotherapies.

Main Results:

Seizures in RE are often refractory to standard anti-seizure medications and conventional immunotherapies.
Hemispherotomy can achieve seizure cessation but results in permanent motor and cognitive deficits.
Evidence suggests a T-cell mediated immunopathogenic mechanism underlying RE.

Conclusions:

Early diagnosis of RE is critical to prevent severe neurological and cognitive consequences.
Novel biotherapies targeting cytokines offer promising therapeutic avenues.
Managing RE requires a multidisciplinary approach, addressing diagnostic, therapeutic, and surgical challenges.