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Membrane occupation and recognition nexus (MORN) motif controls protein localization and function
Jinrun Zhou1, Honghong Liu1, Yushuang Lin1
1Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao, China.
FEBS Letters
|May 15, 2022
Summary
The membrane occupation and recognition nexus (MORN) motif is found in diverse organisms and cell types. Research highlights its roles in muscle stability and cancer, suggesting therapeutic potential for diseases like cardiovascular conditions.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- The membrane occupation and recognition nexus (MORN) motif was first identified in junctophilins in 2000.
- MORN motifs are present in proteins across various organisms, including parasites, plants, and animals.
- These proteins exhibit diverse intracellular localizations, indicating multifaceted physiological roles.
Purpose of the Study:
- To review current research on MORN motif-containing proteins.
- To explore the diverse functions and applications of MORN motif proteins.
- To provide insights for future research directions.
Main Methods:
- Literature review of published studies on MORN motif proteins.
- Analysis of MORN motif protein expression and localization.
- Examination of MORN motif protein involvement in physiological and pathological processes.
Main Results:
- MORN motif proteins are expressed in most animal and plant cell types.
- Recent studies link MORN motif proteins (e.g., junctophilin-1/2, MORN3) to cardiac hypertrophy, muscle stability, and cancer.
- The diverse functions suggest broad physiological relevance.
Conclusions:
- MORN motif proteins are crucial in various biological contexts.
- Their involvement in diseases like cardiovascular conditions indicates therapeutic potential.
- Further exploration of MORN motif protein functions and applications is warranted.
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