Multifunctional Arabinoxylan-functionalized-Graphene Oxide Based Composite Hydrogel for Skin Tissue Engineering
Muhammad Umar Aslam Khan1,2, Saiful Izwan Abd Razak1,3, Anwarul Hassan4,5
1BioInspired Device and Tissue Engineering Research Group, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
Frontiers in Bioengineering and Biotechnology
|May 16, 2022
Summary
This study developed advanced composite hydrogels from arabinoxylan and graphene oxide (GO) for effective wound healing. These novel materials demonstrate significant antibacterial, anticancer, and biocompatible properties, accelerating wound closure in vivo.
Area of Science:
- Biomedical Engineering
- Materials Science
- Regenerative Medicine
Background:
- Wound healing is a complex physiological process requiring effective treatments.
- Developing multifunctional materials that prevent infection and promote healing is crucial for biomedical applications.
Purpose of the Study:
- To create novel composite hydrogels with enhanced wound healing properties.
- To investigate the structural, mechanical, and biological activities of these hydrogels.
Main Methods:
- Functionalization of arabinoxylan and graphene oxide (GO) via hydrothermal method.
- Cross-linking GO-arabinoxylan and polyvinyl alcohol (PVA) with tetraethyl orthosilicate (TEOS).
- Characterization using FTIR, SEM, water contact angle, mechanical testing, swelling, and biodegradation studies.
Main Results:
- Composite hydrogels exhibited enhanced antibacterial activity against E. coli, S. aureus, and P. aeruginosa.
- Effective anticancer and biocompatibility demonstrated against U-87 and MC3T3-E1 cell lines.
- In vivo studies showed accelerated wound healing in a mouse model within 7 days with improved vascularization and minimal inflammation.
Conclusions:
- The developed composite hydrogels possess significant multifunctional properties for wound healing.
- These materials show potential as advanced wound dressing materials in biomedical engineering.
