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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

353
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
353
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

413
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
413
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

251
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
251
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

235
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
235
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

548
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
548
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

646
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
646

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Updated: Sep 23, 2025

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Ulcerative colitis after SARS-CoV-2 infection.

Sofia Kartsoli1, Spyridon Vrakas1, Dimitrios Kalomoiris2

  • 1Tzaneio General Hospital of Piraeus, Department of Gastroenterology, Piraeus, Greece.

Autopsy & Case Reports
|May 16, 2022
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Summary
This summary is machine-generated.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may trigger new-onset ulcerative colitis. COVID-19 can alter gut microbiota and immune responses, potentially leading to inflammatory bowel disease.

Keywords:
COVID-19SARS-CoV-2Ulcerative colitis

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Immunology

Background:

  • Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) primarily targets the respiratory system but also affects the gastrointestinal (GI) tract.
  • Emerging evidence suggests a link between COVID-19 and GI manifestations, including inflammatory bowel disease (IBD).

Observation:

  • A case report of a 74-year-old male diagnosed with new-onset ulcerative colitis (UC) following a SARS-CoV-2 infection.
  • The patient experienced typical COVID-19 symptoms including fever, rhinorrhea, and diarrhea prior to UC diagnosis.

Findings:

  • Studies indicate significant gut microbiota dysbiosis and altered immune responses in COVID-19 patients.
  • These changes may predispose individuals to chronic inflammation and the development of IBD.
  • Review of additional cases suggests a pattern of UC onset post-SARS-CoV-2 infection.

Implications:

  • SARS-CoV-2 infection could be an environmental trigger for IBD in susceptible individuals.
  • Further research is needed to elucidate the precise mechanisms linking COVID-19 to GI inflammation.
  • Understanding these mechanisms may lead to novel therapeutic strategies for both viral infections and IBD.