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[A Survey on the Concomitant Use of Drugs with Enzalutamide in Medical Practice-The Effects and Resultant Decrease in
Satoko Arai1, Keiichi Koido, Aiko Maejima
1Dept. of Urology, National Cancer Center Hospital.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|May 17, 2022
Summary
Enzalutamide can decrease the effectiveness of other medications due to enzyme induction. This study found that many patients taking enzalutamide also took other drugs, potentially leading to reduced efficacy and adverse events like high blood pressure.
Area of Science:
- Oncology
- Pharmacology
- Drug Interactions
Background:
- Enzalutamide is a potent inducer of cytochrome P450 enzymes.
- This induction can affect the metabolism of co-administered drugs, potentially reducing their efficacy.
- Precautions are advised for certain drug combinations with enzalutamide.
Purpose of the Study:
- To investigate the real-world impact of enzalutamide on concomitant medications.
- To identify drugs affected by enzyme induction during co-administration with enzalutamide.
- To assess the clinical significance of these drug interactions.
Main Methods:
- Retrospective analysis of patient medical records.
- Inclusion criteria: patients with castration-resistant prostate cancer treated with enzalutamide.
- Data collected: enzalutamide use duration, concomitant medications, laboratory values, and adverse events.
Main Results:
- 107 patients were analyzed; 64% were on drugs susceptible to enzyme induction.
- Warfarin and omeprazole were among the listed interacting drugs.
- Potential efficacy reduction was observed, with events including elevated blood pressure and blood clots.
Conclusions:
- Enzalutamide's enzyme-inducing properties can weaken the effects of co-administered medications.
- Clinical monitoring is crucial when enzalutamide is used with other drugs.
- Further research may be needed to fully characterize these interactions.
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