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Updated: Sep 22, 2025

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
[Does high-dose intravenous vitamin C has anti-cancer activity ?]
Marie-Gabrielle Courtes1, Nathalie Baudoux1, Christoforos Astaras1
1Service d'oncologie, Hôpitaux universitaires de Genève, 1211 Genève 14.
Abstract:
High-dose intravenously (i.v) vitamin C in cancer patients is controversial. Numerous studies carried out on cancer cell lines and animal models demonstrated that millimolar vitamin C concentrations inhibit tumor cells viability, especially in association with chemotherapy. In cancer patients, high-dose i.v vitamin C in monotherapy does not show any anti-cancer activity. Clinical trials assessing high-dose i.v vitamin C concomitantly with chemotherapy do not conclude to reliable evidence for tumor control or overall survival benefit. Randomized double-blind trials are warranted.
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