Patent ductus arteriosus and spontaneous intestinal perforation in a cohort of preterm infants

Related Experiment Video

Updated: Sep 22, 2025

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

1.1K

Alessandra Mayer1, Gaia Francescato2, Nicola Pesenti3

  • 1NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Journal of Perinatology : Official Journal of the California Perinatal Association
|May 19, 2022
PubMed

Insights

Treating patent ductus arteriosus (PDA) and its duration are linked to spontaneous intestinal perforation (SIP) in premature infants. Both intervention and non-intervention strategies for PDA show associations with SIP risk.

Area of Science:

  • Neonatal Medicine
  • Pediatric Cardiology
  • Gastroenterology

Background:

  • Patent ductus arteriosus (PDA) is common in preterm infants.
  • Spontaneous intestinal perforation (SIP) is a serious complication in neonates.

Purpose of the Study:

  • To investigate the relationship between PDA characteristics (duration, magnitude) and medical treatments with SIP incidence.
  • To determine if PDA management strategies influence SIP risk.

Main Methods:

  • Retrospective chart review of infants born <29 weeks gestation (2006-2018).
  • Evaluation of echocardiographic findings using the McNamara and Sehgal staging system.

Main Results:

  • Infants with SIP had a higher incidence of hemodynamically significant PDA (HSPDA) and received NSAIDs or paracetamol more frequently.
  • Persistence of HSPDA increased SIP odds by 1.32 per day in untreated infants.
  • Treatment of non-HSPDA was associated with a 2.35 increase in SIP odds per drug dose.

Conclusions:

  • Both medical treatment of non-hemodynamically significant PDA and non-intervention for HSPDA are associated with SIP.
  • PDA management requires careful consideration of potential SIP risks.
Abstract

More Related Videos

Transuterine Fetal Tracheal Occlusion Model in Mice06:31

Transuterine Fetal Tracheal Occlusion Model in Mice

Published on: February 5, 2021

3.2K
Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs06:25

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs

Published on: March 5, 2016

9.6K

Related Concept Videos

Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
184
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
155