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Related Concept Videos

Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
Microbial Interactions: Cooperation01:26

Microbial Interactions: Cooperation

Microbial cooperation involves beneficial interactions in which different species work together for individual or mutual advantage. These interactions can profoundly influence ecological dynamics and evolutionary processes, and they are essential to many pathogenic and symbiotic relationships.Nematode–Bacteria CooperationA striking example is the relationship between the Gram-negative bacterium Xenorhabdus nematophila and the parasitic nematode Steinernema carpocapsae. Juvenile nematodes...
Microbial Interactions: Predation01:28

Microbial Interactions: Predation

Microbial predation refers to the process by which one microorganism kills and consumes another to obtain nutrients and energy. It encompasses both bacterial and protozoan predators. This interaction plays a crucial role in shaping microbial communities and regulating nutrient cycling.Bacterial Predators: Epibiotic vs. EndobioticBacterial predators are classified based on their mode of attack as either epibiotic or endobiotic. Epibiotic predators, such as Vampirococcus, attach to the surface of...
Probiotics01:22

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

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Updated: Jun 7, 2026

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
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Can Postbiotics Represent a New Strategy for NEC?

Maria Lorella Giannì1,2, Daniela Morniroli1,2, Fabio Mosca3,4

  • 1Fondazione I.R.C.C.S. Ca' Granda Ospedale Maggiore Policlinico, Neonatal Intensive Care Unit, Milan, Italy.

Advances in Experimental Medicine and Biology
|July 26, 2024
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Summary

Postbiotics, beneficial compounds from gut microbes, can improve infant gut health without live bacteria. These substances show promise in preventing necrotizing enterocolitis (NEC) in newborns.

Keywords:
MicrobiotaNecrotizing enterocolitisPostbioticsPreventive strategySignalling

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Area of Science:

  • Microbiology
  • Neonatal Medicine
  • Gastroenterology

Background:

  • Gut microbiota plays a crucial role in human health.
  • Bacterial viability is not always required for beneficial effects.
  • Postbiotics are soluble microbial byproducts with therapeutic potential.

Purpose of the Study:

  • To explore the role of postbiotics in infant gut health.
  • To investigate the potential of postbiotics in preventing necrotizing enterocolitis (NEC).

Main Methods:

  • Review of current research on postbiotics and gut health.
  • Analysis of postbiotic mechanisms in modulating gut microbiota and immunity.

Main Results:

  • Postbiotics can shape gut microbiota composition.
  • They possess immune-modulatory activities and enhance gut barrier integrity.
  • Postbiotics show promise in reducing NEC risk in preterm infants by lowering inflammation and promoting beneficial bacteria.

Conclusions:

  • Postbiotics represent a significant advancement in neonatal care.
  • They offer a viable strategy to prevent severe intestinal disorders like NEC.
  • Further research into postbiotics can optimize newborn intestinal health.