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Updated: Aug 23, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
Published on: August 30, 2016
An Organ-on-a-Chip System to Study Anaerobic Bacteria in Intestinal Health and Disease
Locke Davenport Huyer1, Milica Radisic1
1Department of Chemical Engineering and Applied Chemistry, Institute of Biomedical Engineering University of Toronto, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Abstract:
A state-of-the-art organ-on-a-chip system enabled co-culture of highly oxygen-sensitive Faecalibacterium prausnitzii with human intestinal epithelial cells, recapitulating a critical role of the bacteria in the maintenance of anti-inflammatory phenotype of gut epithelium mediated by bacteria-secreted butyrate.
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