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Related Experiment Video

Updated: Sep 22, 2025

Protocol to Create Chronic Wounds in Diabetic Mice
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Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

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Finding healing where it hurts.

Jay Gill1

  • 1Medical Scientist Training Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.

Med (New York, N.Y.)
|May 19, 2022
PubMed
Summary
This summary is machine-generated.

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Phases of Wound Repair01:28

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Inflammatory Response01:28

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Fractures: Bone Repair01:27

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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The Rising Black Scientist Award (RBSA) supports young Black scientists. This year, Charleese Williams and Elle Lett won, with Jay Gill’s story also highlighted for its global health impact.

Area of Science:

  • Biomedical Sciences
  • Health Equity

Background:

  • The Rising Black Scientist Award (RBSA) Essay Contest aims to foster emerging Black scientists.
  • Cell Press and Cell Signaling Technology organized the second annual contest in 2021.

Purpose of the Study:

  • To recognize and support talented young Black scientists.
  • To highlight impactful stories resonating with global health improvement.

Main Methods:

  • Awarding undergraduate and post-graduate scholars.
  • Featuring exceptional essays and personal journeys.

Main Results:

  • Charleese Williams and Elle Lett were named the 2021 RBSA undergraduate and post-graduate scholars.
  • Jay Gill's story was highlighted for its alignment with Med journal's mission.

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Related Experiment Videos

Last Updated: Sep 22, 2025

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

20.6K
Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

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Conclusions:

  • The RBSA successfully identifies and supports promising young Black scientists.
  • Highlighting diverse stories reinforces the commitment to advancing global health through scientific excellence.