Personalized medicine: From diagnostic to adaptive

Area of Science:

• Oncology
• Biotechnology
• Personalized Medicine

Background:

• Personalized therapy advancements are hindered by the lack of companion diagnostics.
• Extracellular vesicle (EV)-based liquid biopsies are emerging as a powerful tool for cancer detection and monitoring.

Purpose of the Study:

• To propose adaptive therapy as a novel approach to cancer treatment.
• To explore the integration of EV liquid biopsies with adaptive therapy for enhanced personalized medicine.

Main Methods:

• Reviewing the principles of adaptive radiation therapy and its reliance on imaging for tumor monitoring.
• Discussing the potential of EV liquid biopsies for continuous monitoring of tumor dynamics.
• Theorizing the application of adaptive therapy in medical oncology based on real-time patient data.

Main Results:

• Adaptive therapy, informed by EV liquid biopsies, allows for real-time adjustments to treatment plans.
• This approach mirrors successful adaptive strategies in radiation oncology.
• Continuous monitoring of tumor changes facilitates more precise therapeutic interventions.

Conclusions:

• Adaptive therapy holds significant promise for advancing personalized cancer care.
• The synergy between EV liquid biopsies and adaptive treatment strategies can overcome current limitations in precision medicine.
• Future research should focus on clinical implementation and overcoming associated challenges.