Related Experiment Video

Updated: Sep 22, 2025

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump
06:08

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump

Published on: March 11, 2017

10.7K

Compatibility and Stability of Ten Commonly Used Clinical Drugs in Pediatric Electrolyte Supplements Injection

Hongxin Shen1,2,3, Yuzhi Fu1,2,3, Ying Chen1,2,3

  • 1Department of Pharmacy, West China Second University Hospital of Sichuan University, Chengdu, People's Republic of China.

Drug Design, Development and Therapy
|May 20, 2022
PubMed

Insights

Pediatric electrolyte supplements injection is stable with nine common drugs for 6 hours. Mezlocillin sodium is not recommended due to particle issues, ensuring pediatric patient safety.

Area of Science:

  • Pediatric pharmacology
  • Clinical pharmacy
  • Drug compatibility studies

Background:

  • Pediatric electrolyte supplements injection is crucial for fluid and heat balance in children.
  • Limited data exists on the compatibility and stability of these injections with common antibiotics.
  • Ensuring drug safety and rational use in pediatric patients is paramount.

Purpose of the Study:

  • To evaluate the physical and chemical stability of pediatric electrolyte supplements injection when mixed with ten common clinical drugs.
  • To assess the safety and efficacy of co-administered drugs in pediatric electrolyte solutions.

Main Methods:

  • Pediatric electrolyte supplements injection was mixed with ten drugs at clinical concentrations.
  • Physicochemical compatibility was assessed through visual inspection, insoluble particle counts, pH monitoring, and HPLC analysis over 6 hours.
  • Testing adhered to Chinese Pharmacopeia (2020) standards.

Main Results:

  • No significant changes in appearance were observed upon mixing.
  • pH levels remained within acceptable ranges for all mixtures.
  • Insoluble particle counts met standards for nine drugs; mezlocillin sodium exceeded limits.
  • Active ingredient concentrations remained above 97% for all mixtures within 6 hours.

Conclusions:

  • Nine common clinical drugs are stable in pediatric electrolyte supplements injection for 6 hours under standard conditions (25°C, protected from light).
  • Mezlocillin sodium for injection is not recommended for co-administration due to exceeding insoluble particle standards.
  • These findings support the safe and rational use of pediatric electrolyte supplements in combination with specific medications.
Abstract

Keywords:
compatibilitypediatric electrolyte supplements injectionstability

More Related Videos

Standardized Measurement of Nasal Membrane Transepithelial Potential Difference NPD09:47

Standardized Measurement of Nasal Membrane Transepithelial Potential Difference NPD

Published on: September 13, 2018

16.6K
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.0K

Related Concept Videos

Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.4K
Electrolytes: van't Hoff Factor03:08

Electrolytes: van't Hoff Factor

Colligative Properties of Electrolytes
The colligative properties of a solution depend only on the number, not on the identity, of solute species dissolved. The concentration terms in the equations for various colligative properties (freezing point depression, boiling point elevation, osmotic pressure) pertain to all solute species present in the solution. Nonelectrolytes dissolve physically without dissociation or any other accompanying process. Each molecule that dissolves yields one...
34.1K
Introduction to Electrolytes01:33

Introduction to Electrolytes

In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
13.2K
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
409
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
2.0K
Bioequivalence: Overview01:16

Bioequivalence: Overview

Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
1.2K