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Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity

Shuhei Kawamura1, Rachel L Palte2, Hai-Young Kim3

  • 1Discovery Chemistry, Merck & Co., Inc., Boston, MA 02115, United States.

Bioorganic & Medicinal Chemistry
|May 20, 2022
PubMed

Keywords:
CyclonucleosideMedicinal chemistryMolecular modelingNucleosidePRMT5PRMT5 inhibitorX-ray crystallography

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