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Conventional Therapies for Crohn's Disease
Stacey Rolak1, Sunanda V Kane2
1Department of Internal Medicine, Mayo Clinic College of Medicine and Science, 200 First Street, Southwest, Rochester, MN 55905, USA.
Gastroenterology Clinics of North America
|May 20, 2022
Summary
Crohn
Area of Science:
- Gastroenterology and immunology, focusing on immune-mediated gastrointestinal disorders.
Background:
- Crohn's disease is a chronic, progressive immune-mediated condition with rising global incidence.
- Currently, no curative treatments exist for Crohn's disease.
Purpose of the Study:
- To review the therapeutic landscape for Crohn's disease, emphasizing current treatment modalities.
- To discuss the roles of various agents in inducing and maintaining disease remission.
- To highlight the different classes of biologic therapies and the importance of personalized treatment selection.
Main Methods:
- Literature review of primary agents used in Crohn's disease management.
- Categorization of treatments including aminosalicylates, corticosteroids, immunomodulators, and biologics.
- Analysis of biologic therapies: anti-TNF agents, anti-integrins, and anti-interleukins.
Main Results:
- Aminosalicylates, corticosteroids, and immunomodulators are foundational treatments.
- Biologics offer advanced therapeutic options for Crohn's disease management.
- Different biologics target distinct inflammatory pathways.
Conclusions:
- Treatment selection for Crohn's disease requires a comprehensive understanding of available therapies.
- Shared decision-making between patients and providers is crucial for optimizing initial biologic therapy choice.
- Personalized treatment strategies are essential for managing this chronic condition.
Keywords:
AminosalicylatesAnti-IntegrinsAnti-TNFAnti-interleukinsBiologicsCrohn’s diseaseImmunomodulatorsTreatmentsMore Related Videos
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