Continuously Multiplexed Ultrastrong Raman Probes by Precise Isotopic Polymer Backbone Doping for Multidimensional...

Area of Science:

• Materials Science
• Spectroscopy
• Polymer Chemistry

Background:

• Raman-based super multiplexing is crucial for imaging, biological analysis, security, and data storage.
• A significant challenge is synthesizing diverse Raman-active molecules for a broad Raman color palette.
• Existing methods struggle to provide the necessary range and tunability for advanced multiplexing applications.

Purpose of the Study:

• To develop a facile and systematic strategy for constructing continuously multiplexed ultrastrong Raman probes.
• To create a library of Raman probes with tunable frequencies and adjustable signal intensities.
• To demonstrate the application of these probes in novel information encryption and data storage systems.

Main Methods:

• Incorporation of varying ratios of Carbon-13 (¹³C) isotope into the poly(deca-4,6-diynedioic acid) (PDDA) backbone.
• Characterization of the resulting ¹³C-doped PDDA library for Raman frequency and intensity tuning.
• Utilizing the doped PDDAs as security inks to create a 3D matrix barcode system.

Main Results:

• A library of ¹³C-doped PDDAs was successfully synthesized with tunable double-bond Raman frequencies.
• Adjustable intensity ratios of ¹³C≡¹³C and ¹²C≡¹²C triple-bond Raman peaks were achieved.
• Ultrastrong Raman signals and inherent physicochemical properties of the polymer were maintained.
• Demonstrated successful application as security inks for a novel 3D matrix barcode system.

Conclusions:

• The ¹³C-doped PDDA series offers a new pathway for advancing Raman-based super multiplexing.
• This approach provides a versatile platform for diverse applications requiring high-performance Raman probes.
• The developed technology enables enhanced information encryption and high-density data storage solutions.