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Updated: Sep 22, 2025

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
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Signaling oscillations in embryonic development.

Sabine L Bosman1, Katharina F Sonnen1

  • 1Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, Utrecht, The Netherlands.

Current Topics in Developmental Biology
|May 23, 2022
PubMed
Summary

Signaling oscillations are dynamic cell communication patterns crucial for embryonic development. These rhythmic signals regulate cell fate and tissue formation, like vertebrate segmentation.

Keywords:
ERK signalingEmbryonic developmentNOTCH signalingNeural developmentPancreas developmentSignaling oscillationsSignaling pathwaysSomitogenesisWNT signaling

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Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Systems Biology

Background:

  • Embryonic development relies on precise spatiotemporal control of cellular behavior and fate.
  • Intercellular communication through dynamic signaling pathways mediates this control.
  • Signaling oscillations, a specific dynamic pattern, are observed in various pathways and systems.

Purpose of the Study:

  • To review the current understanding of signaling oscillations in embryonic development.
  • To explain the generation and study of signaling oscillations.
  • To highlight the role of signaling oscillations in regulating embryonic development.

Main Methods:

  • Literature review of signaling oscillations in embryonic development.
  • Analysis of mechanisms generating signaling oscillations.
  • Discussion of experimental approaches to study these dynamics.

Main Results:

  • Signaling oscillations regulate periodic events and transmit information through dynamic properties.
  • Examples include modulation of neural and pancreatic progenitor cell proliferation and differentiation.
  • Synchronized oscillations between cells can form waves, regulating processes like vertebrate somitogenesis.

Conclusions:

  • Signaling oscillations are fundamental to embryonic development.
  • Understanding their generation and function is key to deciphering developmental processes.
  • These dynamic patterns play critical roles in tissue formation and cell fate decisions.