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Signaling switches: Metabolism regulates gastruloid self-organization

María J Rodríguez Colman1, Katharina F Sonnen2

  • 1Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CG Utrecht, the Netherlands; Oncode Institute, Utrecht, the Netherlands.

Cell Stem Cell
|May 2, 2025
PubMed
Summary

Metabolic activity significantly impacts embryonic development. The balance between glycolysis and oxidative phosphorylation controls cell fate decisions during gastruloid formation from mouse stem cells.

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