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GEOexplorer: a webserver for gene expression analysis and visualisation.

Guy P Hunt1,2,3,4, Luigi Grassi5, Rafael Henkin6

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Summary
This summary is machine-generated.

GEOexplorer simplifies gene expression analysis for scientists. This webserver allows easy access, integration, and analysis of microarray and RNA-seq data from the Gene Expression Omnibus (GEO) without programming skills.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Computational Biology

Background:

  • Gene Expression Omnibus (GEO) hosts vast public gene expression data.
  • Analyzing and integrating this data requires specialized bioinformatics expertise and programming skills.
  • Accessibility challenges limit broader scientific use of valuable gene expression datasets.

Purpose of the Study:

  • To develop a user-friendly webserver, GEOexplorer, for accessing and analyzing gene expression data.
  • To enable scientists to perform complex analyses without programming proficiency.
  • To facilitate interactive and reproducible gene expression analysis of public and user-generated data.

Main Methods:

  • Development of a webserver with a graphical user interface.
  • Integration of capabilities to search and retrieve data from GEO.
  • Implementation of tools for data uploading, harmonization, and joint analysis.
  • Support for both microarray and RNA-seq data formats.

Main Results:

  • GEOexplorer provides an accessible platform for gene expression data analysis.
  • Users can perform interactive and reproducible analyses, including differential gene expression.
  • The tool generates interactive visualizations and publication-ready figures.
  • Facilitates on-the-fly exploratory data analysis for life scientists.

Conclusions:

  • GEOexplorer empowers life scientists by removing technical barriers to gene expression data analysis.
  • The webserver promotes reproducible research and facilitates data-driven biological discovery.
  • It enhances the utility of public gene expression repositories like GEO for a wider research community.